{"id":3157,"date":"2025-03-02T00:15:06","date_gmt":"2025-03-01T22:15:06","guid":{"rendered":"https:\/\/santamonica.lv\/?page_id=3157"},"modified":"2025-03-05T22:44:28","modified_gmt":"2025-03-05T20:44:28","slug":"artesunate","status":"publish","type":"page","link":"https:\/\/santamonica.lv\/sv\/for-halsan\/artesunate\/","title":{"rendered":"Artesunate"},"content":{"rendered":"\n
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Artesunate \u00e4r ett artemisininderivat erh\u00e5llet fr\u00e5n den kinesiska v\u00e4xten Artemisia\u00a0annua<\/em>, eller kinesisk mal\u00f6rt. Det har anv\u00e4nts i \u00e5rhundraden i asiatiska l\u00e4nder som ett traditionellt botemedel f\u00f6r att behandla infektioner.<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u00c5r 2015 fick den kinesiske forskaren Tu Youyou Nobelpriset f\u00f6r forskning som utf\u00f6rts med artemisinin f\u00f6r att behandla malaria. Men av en slump visade det sig att denna f\u00f6rening ocks\u00e5 har anti-canceraktivitet. Det observerades att de kvinnor som hade br\u00f6stcancer och fick artemisinin f\u00f6r att behandla malaria, efter en tid s\u00e5g en betydande f\u00f6rb\u00e4ttring och i vissa fall till och med en fullst\u00e4ndig remission av tum\u00f6ren. Av denna anledning \u00e4r artesunat k\u00e4nt som ett \u00e4mne med anticanceraktivitet. Detta bevisas av flera hundra unders\u00f6kningar och publikationer.<\/p>\n\n\n\n

Verkningsmekanismen f\u00f6r artesunat, som f\u00f6rst\u00f6r tum\u00f6rceller, \u00e4r f\u00f6rst\u00f6relsen av j\u00e4rnhaltiga proteiner i cancercellens cytoplasma. En annan farmakologisk effekt har uppt\u00e4ckts som hj\u00e4lper till att bek\u00e4mpa cancerceller. Artesunate undertrycker bildandet av nya blodk\u00e4rl i tum\u00f6rv\u00e4vnad (neoangiogenes). Som ett resultat f\u00e5r tum\u00f6ren inte de n\u00f6dv\u00e4ndiga n\u00e4rings\u00e4mnena, och dess tillv\u00e4xt h\u00e4mmas.Det har l\u00e4nge varit k\u00e4nt att snabbt prolifererande cancerceller aktivt attraherar j\u00e4rn. Som ett resultat utvecklar onkologiska patienter anemi efter en kort tid, vilket visar sig som tr\u00f6tthet. Artesunate-infusioner hj\u00e4lper till att bevara j\u00e4rndep\u00e5er i kroppen om intraven\u00f6sa preparat som inneh\u00e5ller j\u00e4rn administreras innan de p\u00e5b\u00f6rjas eller parallellt med administrering av artesunat. D\u00e5 binder artesunat till j\u00e4rnet i plasman, som i sin tur binder till j\u00e4rntransportmolekylen \u2013 transferrinreceptorer. Till skillnad fr\u00e5n normala celler finns det m\u00e5nga transferrinreceptorer p\u00e5 ytan av tum\u00f6rceller. Med hj\u00e4lp av specifika receptorer infiltrerar j\u00e4rnartesunatkomplex tum\u00f6rceller, d\u00e4r cytotoxiska reaktioner b\u00f6rjar i deras cytoplasma och aggressiva fria syreradikaler frig\u00f6rs, som irreversibelt f\u00f6rst\u00f6r cancerceller fr\u00e5n insidan.<\/p>\n\n\n\n

Artesunate \u00e4r en biologiskt aktiv substans som endast l\u00f6ser sig i en alkalisk milj\u00f6, s\u00e5 f\u00f6re administrering l\u00f6ses den med en bikarbonatl\u00f6sning i upp till 5 minuter och sp\u00e4ds f\u00f6rst d\u00e4refter med en steril natriumkloridl\u00f6sning. Det rekommenderas inte att administrera samtidigt med vitamin C och andra biologiska preparat, det \u00e4r att f\u00f6redra att observera ett intervall p\u00e5 minst 1 timme. Infusionen ska g\u00f6ras i\/v l\u00e5ngsamt, cirka 60 minuter.<\/p>\n\n\n\n

Som regel tolererar patienter detta preparat v\u00e4l, illam\u00e5ende och yrsel observeras i s\u00e4llsynta fall. Behandlingsf\u00f6rloppet inkluderar 15-20 infusioner, det rekommenderas att \u00f6vervaka blodprov varje vecka, eftersom detta preparat kan minska antalet erytrocyter.<\/p>\n","protected":false},"excerpt":{"rendered":"

Artesunate \u00e4r ett artemisininderivat erh\u00e5llet fr\u00e5n den kinesiska v\u00e4xten Artemisia\u00a0annua, eller kinesisk mal\u00f6rt. Det har anv\u00e4nts i \u00e5rhundraden i asiatiska l\u00e4nder som ett traditionellt botemedel f\u00f6r att behandla infektioner. \u00c5r 2015 fick den kinesiske forskaren Tu Youyou Nobelpriset f\u00f6r forskning som utf\u00f6rts med artemisinin f\u00f6r att behandla malaria. Men av en slump visade det sig…<\/p>\n","protected":false},"author":3,"featured_media":2670,"parent":2373,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"class_list":["post-3157","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nArtesunate - Santa Monica<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/santamonica.lv\/sv\/for-halsan\/artesunate\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Artesunate - Santa Monica\" \/>\n<meta property=\"og:description\" content=\"Artesunate \u00e4r ett artemisininderivat erh\u00e5llet fr\u00e5n den kinesiska v\u00e4xten Artemisia\u00a0annua, eller kinesisk mal\u00f6rt. 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